Tenoflex 20mg Tablet

Uses of Tenoflex 20mg Tablet

• Rheumatoid Arthritis
• Osteoarthritis
• Ankylosing Spondylitis
• Acute Gout
• Post-operative pain
• Primary Dysmenorrhea

How does Tenoflex 20mg Tablet work?

Tenoflex is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

Side Effects of Tenoflex 20mg Tablet

Dyspepsia, nausea, abdominal pain and discomfort, constipation, diarrhea, flatulence, indigestion, epigastric distress, stomatitis, anorexia; peripheral edema; headache, dizziness; allergic reactions, asthma, bronchospasm, dyspnea, rash, pruritus; decreased Hb, anemia, thrombocytopenia, non-thrombocytopenic purpura, leukopenia, eosinophilia, epistaxis; increased serum transaminase levels; swollen eyes, blurred vision, eye irritation, malaise, tinnitus; edema, HTN, cardiac failure. Potentially Fatal: Peptic ulceration, GI bleeding, anaphylaxis, Lyell's syndrome, Stevens-Johnson syndrome, exfoliative dermatitis, nephrotoxicity, arterial thrombotic events (e.g., MI or stroke), hepatitis, jaundice.

Quick Suggestions:

• Inform your doctor if you have ever been diagnosed with kidney or liver problems.
• It should be taken with food or milk to avoid getting an upset stomach.
• It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
• Tenoflex can raise your risk of blood clots, heart attack, or stroke.
• Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Indication:

• Pain and inflammation associated with musculoskeletal and joint disorders

Pharmacology

Tenoxicam is a potent inhibitor of prostaglandin synthesis by blocking the enzyme cyclo-oxygenase. Additional actions contributing to its anti-inflammatory effect include inhibition of leucocyte function, including phagocytosis and chemotaxis, and scavenging free O2 radicals. It has no effect on renal function at the usual doses.

Dosage & Administration:

• Acute musculoskeletal disorders; Osteoarthritis; Rheumatoid arthritis
• Adult: 20 mg as a single dose, taken at the same time each day.
• Max: 40 mg/day (short-term use).
• Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.
• Elderly: Use the lowest effective dose for the shortest possible duration.
• Should be taken with food. Take with or immediately after meals.

Interaction

Increased risk of adverse effects (particularly GI) with salicylates and other NSAIDs. May enhance the anticoagulant effect of warfarin and other anticoagulants. May reduce the effect of antihypertensive drugs. Increased risk of nephrotoxicity with ciclosporin. Increased risk of convulsions with quinolones. May decrease the elimination of lithium. May interfere with the natriuretic action of diuretics. May enhance the toxicity of methotrexate. May reduce the effects of mifepristone. Increased risk of GI bleeding with corticosteroids.

Contraindications

Active or history of recurrent GI bleeding or peptic ulcer, hypersensitivity to NSAIDs, severe heart failure, hemorrhagic diathesis, asthma, pregnancy (3rd trimester).

Pregnancy & Lactation

NSAIDs have an inhibitory effect on prostaglandin synthesis and, when given during late pregnancy, may cause the closure of the fetal ductus arteriosus, prolong labor, and delay parturition. Treatment during the third trimester of pregnancy should be avoided. Based on findings from single-dose administration, a very small amount (approximately 0.2%) of Tenoflex 20mg Tablet passes into breast milk. There is no evidence of adverse reactions in breastfed infants of mothers taking Tenoflex 20mg Tablet. Nevertheless, infants should be weaned or the drug discontinued.

Precautions & Warnings

Patients with a history of or active bronchial asthma, uncontrolled HTN, CHF, established ischemic heart disease, peripheral arterial disease, cerebrovascular disease, risk factors for CV disease (e.g., HTN, hyperlipidemia, DM, smoking), history of GI disease, fluid retention, and edema. Patients who will undergo major surgery (e.g., joint replacement). Elderly. Renal and hepatic impairment. Monitoring Parameters: Monitor renal, hepatic, and cardiac functions.

Storage Conditions

Do not store above 30°C, protect from light & moisture. Keep out of the reach of children.